Biomedical Engineering Reference
In-Depth Information
1
mm
Figure 4.11.
MicroCT 3D reconstruction showing the hollow implant fi lled with MBCP Gel
and bone trabeculae forming a shell at the surface of the implant with bone bridges perpen-
dicular to the implant surface.
we obtained bone growth at the expense of the composite. Histology and micro
CT were performed to examine the bone ingrowth and the interaction with the
injectable bone substitute. The cooperation of the two materials for the mechani-
cal performance of the composite and high osteogenic bone substitute can pro-
mote new surgical technology.
The hydrolysis of the PL DLLA/CaP composite had no incidence on the
bone ingrowth at the expense of the MBCP gel. It appears that the lactic acid
released by the hydrolysis had no effect on the osteogenic properties of the
MBCP Gel. After 26 weeks, the composite was not fully substituted, only the sur-
face at 200 to 300
m appeared to have been transformed and invaded by newly-
formed bone. The surface of the composite was osteoconductive without fi brous
encapsulation.
This effi ciency can be attributed to the calcium phosphate granules integrated
into the PL DLLA. Certain authors attribute this process to a buffered effect of
the calcium salts particles [71]. PL DLLA/CaP composites will provide suitable
resorbable osteosynthesis associated with a non hardening injectable bone substi-
tute. The PL DLLA/CaP composite can play a part in developping a concept for
resorbable osteosynthesis and dedicated bone substitutes such as MBCP gel. The
synergy of the two medical devices can contribute to new, less invasive, surgical
technology, suppressing the need for a second operation to remove the osteosyn-
thesis. Initial mechanical stability will be attained thanks to the PL DLLA/CaP
composite and major bone ingrowth with secondary mechanical properties simi-
lar to those of natural bone will be achieved over time.
μ
4.4.5 BCP Scaffolds for Bone Tissue Engineering
Reconstruction of large segmental bone defects is still a challenge in either ortho-
pedics or oral oncology situations. Ceramics alone have failed to provide enough
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