Biomedical Engineering Reference
In-Depth Information
4
THE MICRO MACROPOROUS
BIPHASIC CALCIUM
PHOSPHATE CONCEPT FOR
BONE RECONSTRUCTION AND
TISSUE ENGINEERING
Guy Daculsi
1,2
, Franck Jegoux
1,3
, and Pierre Layrolle
1
1
INSERM, Université de Nantes, UMR U791, Faculté de Chirurgie Dentaire,
Place Alexis Ricordeau, 44042 Nantes Cedex 01, France
2
CHU de Bordeaux/INSERM, CIC-Innovations Technologiques
Biomatériaux, Bordeaux France
3
CHU Pontchaillou Service ORL et chirurgie maxillofaciale, Rennes France
Contents
4.1 Overview
102
4.2 Introduction
103
4.3 The Fundamental Physical, Chemical and Biological Properties of Biphasic
Calcium Phosphate Bioceramics
104
4.3.1
Introduction to Macroporosity and Microporosity
104
4.3.2
Physical and Chemical Properties
106
4.3.3
Mechanical Properties
107
4.3.4
Bioactivity, Osteogenic Properties
107
4.3.4.1 Composition
109
4.3.4.2 Dissolution Properties
109
4.3.4.3 Cell Proliferation and Colonization
109
4.3.4.4
In
Vivo
Experiment
109
4.4 Bioceramics: New Developments
113
4.4.1
Microstructure Improvement
113
4.4.2
BCP - Based Macroporous Cements
114
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