Biomedical Engineering Reference
In-Depth Information
6.2
Heart-lung machine in practice.
Table 6.1
Current anti-infl ammatory techniques related to CPB
Pharmacologic
Modifi cation techniques and mechanical devices
Steroid pretreatment
Surface coating
Aprotinin
Condensed circuit
Pexelizumab
Leukocyte depletion
Antioxidants
Ultrafi ltration
Mini-circuits
Leukocyte deactivation
Biosensors
Alternative preconditioning (adenosine, potassium
channel opener)
Heat shock
circuit miniaturization, leukofi ltration, ultrafi ltration, and rapid autologous
priming (Table 6.1). Having a common aim, that of moderating the inap-
propriate host response, there are a number of discrete approaches to this
research from the biomaterial perspective.
6.5.1 Surface treatment
Research into the development of novel surface coating technology remains
one of the most active approaches for moderating blood-biomaterial-
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