Biomedical Engineering Reference
In-Depth Information
the.imaging.depth.can.clearly.be.increased.by.orders.of.magnitude..Given.the.deeper.imaging.depth,.
AO. systems. may. play. potentially. a. more. important. role,. provided. that. this. optical. clearing. does. not.
similarly.eliminate.the.index-of-refraction.inhomogeneity.on.the.optical-wavelength.scale..Finally,.the.
AO.system.may.be.important.for.a.number.of.imaging.applications.involving.microluidic.devices..In.
the.fabrication.of.many.microluidic.devices,.the.material.type.or.thickness.used.in.the.fabrication.of.
the.device.may.not.match.the.requirement.of.the.microscope.objectives.that.are.typically.designed.for.
imaging.through.0.17-mm-thick.glass..In.these.cases,.signiicant.aberrations.can.be.induced,.and.the.
use.of.an.AO.system.may.result.in.an.improvement.in.image.quality.in.these.devices.
Acknowledgments
Parts.of.this.work.appeared.in. Journal of Biomedical Optics .15(4),.040622.(2010).
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