Biomedical Engineering Reference
In-Depth Information
Fig. 3.5
(
a
) Antibody affinity toward the hydrophobic section of A
at various temperatures;
(
b
) average atomic root mean square displacement (RMSD) of amyloid structure from mean configu-
ration on 37
C (protein conformations at defined temperatures were shown) (Adapted from [
41
])
β
enhancement; however, for hydrophilic NPs (e.g., silica) the acceleratory effects on
the fibrillation process can be significantly increased (see Fig.
3.6
for details).
3.6 Problems of Protein Corona
The protein corona can induce several shortcomings into the original aims of
nanomedidine (e.g., significant enhancement of targeting capability). For instance,
it has been claimed that the decoration of protein corona can cover/eliminate the
targeting moieties on the surface of nanomaterials and, thus, strongly reduces
recognition of the targeting ligand by cellular receptors [
42
]. It has been recently
shown that the targeting ability of transferrin-conjugated silica nanoparticles was
