Biomedical Engineering Reference
In-Depth Information
250
200
100 units
catalase
150
100
1000 units
catalase
50
0
addition of H
2
O
2
new addition of H
2
O
2
0,0
2,5
5,0
7,5
10,0
12,5
15,0
time [h]
Fig.19.
On-line monitoring of milk sterilization via H
2
O
2
5
New Hardware Concepts
Biosensors for clinical analysis will probably have the most economic value.
Simple operating systems are required for personal home-monitoring and for
small medical laboratories instead of time-consuming and expensive manual
assays.The most decisive precconditions for this special kind of biosensor are
miniaturized production methods, ease of operation and the possibility of
using small sample volumes. Moreover, the analyzers must have convincing
benefits to compete with existing dip-stick sensors. Thus, the development of
microbiosensors is an active field of research. During the 1990s several re-
searchers have investigated new methods to miniaturize thermal biosensors.
Especially in basic research,new microsystem technologies have been of great
interest. In this section, we would like to review these investigations and re-
present current trends in thermal biosensor development.
5.1
High Resolution Thin-Film Thermistors
As previously shown,thermistors exhibit high sensitivities for monitoring enzy-
matic conversions.Nevertheless,matched thermistor pairs for microbiosensors
are not readily available from industrial suppliers which is limiting for their
Search WWH ::
Custom Search