Description of Instrumentation and Procedures - Advances in Biochemical Engineering Biotechnology - page 31

A hybrid biosensor combining principles of electrochemistry, flow injection
analysis, and calorimetry has also been proposed and developed by us. The con-
cept per se is extremely vital and could be extended to other combinations such
as opto-thermal, etc. An algorithm for other forms of hybrid biosensors is pre-
sently being designed within the group, essentially aimed at extending the ran-
ge of detectable analytes in combination with improved sensitivity and linear
range.The impact of hybrid biosensors,created by interdisciplinary cooperation
would have an immense potential on the developmental success of biosensor
applications. As it has been already demonstrated in the case of thermal and
electrochemical biosensors, it should be possible to extend this application to
other oxidases and dehydrogenases. In addition, this concept is of interest for
developing other hybrid biosensors, such as photoassisted biosensors (light
regeneration of NAD + ) wherein different configurations of the reaction cell for
photochemical reactions could be employed in conjunction with thermometric
sensing.
5
Conclusions
Based on the plethora of applications of thermistor/thermopile based devices, it
can be concluded that the field of thermometric sensing offers several avenues
of progress in materials science, process monitoring, process control, molecular
level detection, characterization of biocatalysts, hybrid sensing and multisens-
ing devices, as well as in telemedicine and other areas of biomedical analysis.
6
References
1. Spink C, Wadsö I (1976) Meth Biochem Anal 23:1
2. Danielsson B, Mosbach K (1986) In: Turner APF, Karube I, Wilson GS (eds) Biosensors:
Fundamentals and Applications. Oxford University Press, Oxford, p 575
3. Danielsson B, Mosbach K (1988) Methods Enzymol 137:181
4. Mosbach K, Danielsson B (1974) Biochim Biophys Acta 364:140
5. Weaver JC, Cooney CL, Fulton SP, Schuler D, Tannenbaum SR (1976) Biochim Biophys Acta
452:285
6. Pennington SN (1976) Anal Biochem 72:230
7. Tran-Minh C,Vallin D (1978) Anal Chem 50:1874
8. Rich S, Ianiello RM, Jesperson ND (1979) Anal Chem 51(2):204
9. Bowers LD, Carr PW (1976) Clin Chem 22:1427
10. Schmidt H-L, Krisam G, Grenner G (1976) Biochim Biophys Acta 429:283
11. Kiba N, Tomiyasu T, Furusawa M (1984) Talanta 31:131
12. Muramatsu H, Dicks JM, Karube I (1987) Anal Chim Acta 197:347
13. Muehlbauer MJ, Guilbeau EJ, Towe BC (1989) Anal Chem 61:77
14. Urban G, Jachimowicz A, Kohl F, Kuttner H, Olcaytug F, Goiser P, Prohaska O (1990) Sens
and Actuators A21-A23:650
15. Scheller F, Siegbahn N, Danielsson B, Mosbach K (1985) Anal Chem 57:1740
16. Mattiasson B, Danielsson B, Mosbach K (1976) Anal. Lett 9:867
17. Danielsson B, Mattiasson B, Mosbach K (1981) Appl Biochem Bioeng 3:97
18. Danielsson B, Gadd K, Mattiasson B, Mosbach K (1976) Anal Lett 9:987