Description of Instrumentation and Procedures - Advances in Biochemical Engineering Biotechnology - page 21

a

b

Fig. 10. a Correlation of glucose measurement in whole blood, measured by micro-thermo-
metric biosensor and by the Reflolux-S blood glucose analyser. b Correlation of glucose mea-
surement in whole blood measured by micro-thermometric biosensor and by the Ektachem
blood glucose analyzer

3.3.2
In-Vivo Monitoring

A miniaturized thermal flow-injection analysis biosensor was coupled with a
microdialysis probe for continuous subcutaneous monitoring of glucose [34].
The system (Scheme 1) consisted of a miniaturized thermal biosensor with a
small column containing co-immobilized glucose oxidase and catalase. The
analysis buffer passed through the column at a flow rate of 60

m l/min via a 1- m l

sample loop connected to a microdialysis probe (Fig. 11).