Protein Glycosylation: Implications for In Vivo Functions and Therapeutic Applications - Advances in Biochemical Engineering Biotechnology - page 158

Table 1. Classification of glycoproteins and nature of linkage

Type of Occurrence Glycan - peptide linkage Anomeric type Stability to acid Stability to alkali

glycosylation

Monosaccharide Amino acid

N-glycosylation

Widespread GlcNAc Asn b + +

O-glycosylation
Mucin Mucin, blood group, fetuin, GalNAc Ser/Thr a + -

antifreeze glycoproteins

Intracellular Nucleus and cytosolic GlcNAc Ser/Thr b

Proteoglycan Proteoglycans Xyl core Ser b + -

Collagen Collagens Gal OH-Lys b ++ ++

Clotting factor Factor IX Fuc/Glc core Ser

Fungal Yeast and Fungal Man Ser/Thr

glycoproteins

Plant Plant cell walls, Ara OH-Pro b -

earthworm, cuticle Gal Ser a + -

GPI anchore

Cell surface receptors