Biomedical Engineering Reference
In-Depth Information
a
b
Fig. 6.
a
Schematic diagram of the sensor construction. T
0
to T
4
represent the film thermistors
0 to 4, respectively. E
1
and E
2
contain enzyme matrices 1 and 2. E
0
represents the region
containing the same carrier beads as the other regions but without immobilized enzymes.
b
Calibration curves for the simultaneous responses of glucose, urea and penicillin in a mix-
ture. Oxygen was electrocatalytically generated in the buffer stream for the glucose oxidase
reactions
were fabricated on the quartz chip along the microchannel with a spacing of
3.5 mm by doping in polysilicon and etching.
The thermistors were electrically insulated by depositing a layer of silicon
oxide (low temperature oxide). The thermistors were then paired in two inde-
pendent groups, T
0
with T
1
and T
2
with T
3
corresponding to the enzyme reac-
tions in region E
1
and E
2
respectively. A silicone-rubber membrane (0.32 mm
thick) formed the reactive channel (17.5
¥
0.8
¥
0.32 mm) and was also used
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