Bioactive Agents from Natural Sources: Trends in Discovery and Application - Advances in Biochemical Engineering Biotechnology - page 117

huperzine A

didemin B

ecteinascidin 743

bryostatin 1

Fig. 7. Clinical candidates from plants and marine environment: Huperzine A, didemnin B,
bryostatin 1,and ecteinascidin 743.

will give rise to synthetic analogs to treat inflammation by interacting with
phospholipase A 2 [132,133].
Recently,Pseudopterosin C,a diterpene riboside isolated from the gorgonian
corals Pseudopterogorgia bipinata and P. elisabethae [134] was launched by
Estée Lauder as an additive to anti-aging cosmetics. It exhibits potent anti-
inflammatory and analgesic activities by reversibly affecting both,lipoxygenase
and phospholipase A 2 [135].

4
Exploitation of Structural Diversity

4.1
Approaches to Access Structural Diversity from Nature

Today,more than 30,000 diseases are clinically described.Less than one third of
these can be treated symptomatically,and only a few can be cured [136].Con-