Multiscale Approach to Understand the Multiphysics Phenomena in Bone Adaptation - Multiscale Computer Modeling in Biomechanics and Biomedical Engineering - page 64

Fig. 11 Toward a new paradigm for bone adaptatione centered on the charged species transport
phenomena. Piezo-electricity and calcium permselectivity may interact in the mechano-
adaptation chain of bone tissue (reproduced with permission from Lemaire and Naili [ 83 ])
the unification of bone biomechanics at the tissue scale and bone mechanobiology
describing the complex cellular interactions could become possible.
References
1. Adachi, T., Kameo, Y., Hojo, M.: Trabecular bone remodelling simulation considering
osteocytic response to fluid-induced shear stress. Philos. T. R. Soc. A 368, 2669-2682 (2010)
2. Ager, J.W. III, Balooch, G., Ritchie, R.O: Fracture, aging, and disease in bone. J. Mater.
Res. 21, 1878-1892 (2006)
3. Ahn, A.C., Grodzinsky, A.J: Relevance of collagen piezoelectricity to wolff's law: a critical
review. Med. Eng. Phys. 31, 733-741 (2009)
4. Ajubi, N.E., Klein-Nulend, J., Nijweide, P.J., Vrijheid-Lammers, T., Alblas, M.J., Burger,
E.H: Pulsating fluid flow increases prostaglandin production by cultured chicken osteocytes-
a cytoskeleton-dependent process. Biochem. Biophys. Res. Commun. 225, 62-68 (1996)
5. Anderson, E., Kreuzer, S., Small, O., Knothe Tate, M.: Pairing computational and scaled
physical models to determine permeability as a measure of cellular communication in
micro- and nano-scale pericellular spaces. Microfluid. Nanofluidics 4, 193-204 (2008)
6. Anderson, E.J., Knothe Tate, M.L: Idealization of pericellular fluid space geometry and
dimension results in a profound underprediction of nano-microscale stresses imparted by
fluid drag on osteocytes. J. Biomech. 41, 1736-1746 (2008)
7. Auriault, J.-L., Adler, P.M.: Taylor dispersion in porous media: analysis by multiple scale
expansions. Adv. Water Res. 18, 217-226 (1995)
8. Auriault, J.-L., Sanchez-Palencia, E.: Etude du comportment macroscopique d'un milieu
poreux saturé déformable. J. Mécanique 16, 575-603 (1977)
9. Baron, R., Tross, R., Vignery, A.: Evidence of sequential remodeling in rat trabecular
bone—morphology, dynamic histomorphometry, and changes during skeletal maturation.
Anat. Rec. 208, 137-145 (1984)