Multiscale Modeling in Vascular Disease and Tissue Engineering - Multiscale Computer Modeling in Biomechanics and Biomedical Engineering - page 249

Fig. 7 The Influence of pulsatile pressure on the number of viable vascular smooth muscle cells
over time in the arterial compliant scaffold, three loading regimes of hypotensive (50-80 mmHg),
normotensive (80-120 mmHg) and hypertensive (140-200 mmHg) were compared. (Image

courtesy of [ 10 ] with permission)

Fig. 8 ECM synthesis and viable VSMCs at day 160 (a, c) the TEBV was cultured under static
pressure of 100 mmHg (b, d) the TEBV was cultured under pulsatile pressure of 80-120 mmHg.
(Image courtesy of [ 10 ] with permission)

scaffold, see Fig. 8 . As such the results imply that to enhance cell growth and reduce
culture time, an initial non-pulsatile luminal pressure can be used until cells fully
populate the scaffold, following which a pulsatile luminal pressure can enhance
ECM synthesis and scaffold remodelling.