Multiscale Modeling in Vascular Disease and Tissue Engineering - Multiscale Computer Modeling in Biomechanics and Biomedical Engineering - page 243

Fig. 2 Schematic of the mechanobiological model of in-stent restenosis (image courtesy of [ 58 ]
with permission)
A significant increase in the level of intimal growth and VSMC number was
predicted by the models when the artery-stent expansion ratio increased from 1.1 to
1.3. This was due to the nonlinear stress-stiffening response of arteries where higher
expansions increased the level of arterial stresses exponentially. This prediction
was verified by comparison to experimental studies which show that the stent
expansion diameter is an important predictor of the level of intimal growth [ 37 - 40 ].