Biomedical Engineering Reference
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Fig. 6 Example of harvested representative trabecular cores from different anatomic sites of a
human femur
mineralization, collagen cross links, …), loading parameters (stress, frequency),
biological parameters (Ca, hormones, …) and the environment (age, gender, risk
factors, drugs, …). For a given trabecular site (a given morphology), it is more
important and more useful to consider the stress applied in the long term because
the processes by which living bones can repair cracks, and adapt their shape
respond generally to altered stress levels [ 4 , 52 ]. In the current investigation, five
factors were selected to develop the NN model.
Three bone relevant morphological and material factors (Table 1 ):
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