Biomedical Engineering Reference
In-Depth Information
binding, surface modification of Ca-P/PHBV nanocomposite scaf-
folds by physical entrapment of gelatin and heparin immobilization
is needed in order to provide the binding site for the growth factor
rhBMP-2.rhBMP-2canbeloadedontosurface-modifiedCa-P/PHBV
scaffolds,andtheimmobilizedheparinnotonlyprovidesameansto
protecttheloadedrhBMP-2butalsoimprovesthesustainedrelease
behavior of rhBMP-2. The integration of advanced scaffold fabrica-
tion technology and nanocomposite and growth factor delivery can
bea very effectivestrategy for bonetissueregeneration.
Acknowledgments
This work was supported by the University of Hong Kong (HKU)
through a research grant in its Basic Research Programme and
by the Hong Kong Research Grants Council (RGC) through GRF
grants(HKU7182/05Eand7181/09E).Assistanceprovidedbystaff
and students in HKU's Department of Mechanical Engineering and
Department of Orthopaedics and Traumatology is gratefully
acknowledged.Prof.C.-S.LiuofEastChinaUniversityofScienceand
Technology, China, isthanked forproviding rhBMP-2.
References
1. P. H. G. Chao, W. Grayson, and G. Vunjak-Novakovic,
J. Orthop. Sci.
,
12
,
398-404 (2007).
2. K. J. L. Burg, S. Porter, and J. F. Kellam,
Biomaterials
,
21
,2347 (2000).
3. C.Laurencin,Y.Khan,andS.F.El-Amin,
Exp. Rev. Med. Dev.
,
3
,49(2006).
4. P.X.Ma,inEd.J.I.Kroschwitz,
Encyclopedia of Polymer Science and Tech-
nol.
(John Wiley &Sons, Hoboken, NJ, 2004), p. 261.
5. L.G.Gri
th and G.Naughton,
Science
,
295
,1009 (2002).
6. S. J. Hollister,
Biofabrication
,
1
, 1 (2009).
7.L.Lu,S.J.Peter,M.D.Lyman,H.L.Lai,S.M.Leite,J.A.Tamada,S.Uyama,
J. P. Vacanti, R. Langer, and A. G. Mikos,
Biomaterials
,
21
,1837 (2000).
8. Q. Yang, L. Chen, X. Y. Shen, and Z. Q. Tan,
J. Macromol. Sci. Part B-Phys.
,
45
,1171 (2006).
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