Biomedical Engineering Reference
In-Depth Information
Figure 44.7.
Micro-CTanalysisofperiodontaldefectsafter6-weekperiod
of healing. (a, b) 2D image of the 3-wall defect transplanted with bTCP (a)
or three-layered PDL cell sheets/bTCP (b). Triangle indicates CEJ of bilat-
eral mandibular first molars of dog. (bar, 1 mm) (c, d) 3D virtual model
of the 3-wall defect transplanted with bTCP (c) or three-layered PDL cell
sheets/bTCP (d). After the 6week healing period, micro-CT analysis was
performedandimageswerereconstructedwithVGmaxsoftware.
Abbrevia-
tion
: CEJ, cement-enamel junction. Reprinted with permission from Ref. 62.
Copyright 2009Elsevier B.V.
Inconclusion,transplantablemultilayeredperiodontalligamentcell
sheets were successfully fabricated with woven poly(glycolic acid),
and its use combined with porous
-tricalcium phosphate induced
true periodontal regeneration, including alveolar bone, cementum,
and well-oriented fibers at the same time. Periodontal ligament cell
sheet transplantation should prove useful for periodontal regenera-
tion in clinicalsettings.
β
44.7 Endoscopic Esophageal Epithelial Transplantation
Endoscopic mucosal resection (EMR) has enabled the noninva-
sive removal of gastrointestinal tract cancers without the need for
esophageal reconstruction.
64
−
67
Although EMR is a widely accepted
technique, the size of treatment is limited, and the retrieval of
multiple specimens, which can damage the tissues, is needed.
68
A
novel method of endoscopic submucosal dissection (ESD) permits
large
en bloc
resections without the size limitation, enabling the
removal of large cancers using a single procedure.
69
−
74
However,
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