EFFECT OF SCAFFOLDS WITH BONE GROWTH FACTORS ON NEW BONE FORMATION - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 896

67% of the autogenous graft group obtained fracture healing. This
method suggested that addition of a growth factor to the allograft
may replace the autogenous graft and overcome the disadvantages
of the autogenous graft, such as the limitation of donor site, pain at
the donor site, and scars. Even though many kinds of growth fac-
tors, stem cells, and scaffolds are being used to find the most e -
cient method for new bone formation in the clinical field, there is
stillnostandardguidelineregardingwhichstemcellsorgrowthfac-
torsorscaffoldsshouldbeselectedtoreducethehealingperiodand
which combination is the best among these biomaterials. The most
important aspects are cost-effectiveness and easy accessibility clin-
ically. Clinically, an absorbable scaffold that can be slightly visible
duringtheinitialstageoffracturehealingontheradiographisbetter
than a nonabsorbable scaffold because the location of the scaffold
should be identified on the radiograph to find out whether or not
this scaffold is placed at the bone defect site. If the scaffold is used
for the defect of long bones of the limbs, the scaffold can move due
to gravity. Duringwalking andexercising,incidenceofdisplacement
of the scaffold increases. Temporary visualization of the scaffold
on conventional radiography requires the development of scaffolds
withadifferentrateofcombinationofnonabsorableandabsorbable
scaffolds.
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