Biomedical Engineering Reference
In-Depth Information
of a rigid frame, which provides stability; however, these materi-
als are radio-opaque. Therefore, it is di
cult to differentiate the
new bone formation from the ceramic scaffolds. In addition, the
bioceramic is brittle and not suited for bone applications. A better
approach is to use a composite of bioceramic and a resorbable poly-
mer.
43.2 Bone Lengthening in Preclinical Animal Studies
Here,wereportafewmethodstoacceleratetheconsolidationrateof
distracted callus formation by the injection of calcium sulfate, cord
blood (CB) stem cell, and human recombinant bone morphogenetic
protein-2 (rhBMP-2).
43.2.1
Calcium Sulfate in Tibial Lengthening
Small monolateral external distraction devices (small bone distrac-
tor; U&I, Kyunggi- Do, Korea) were applied to the diaphysis of the
tibia of New Zealand white rabbits (5-6 months old; 2.0-2.5 kg)
Figure 43.1.
Afterlengtheningoftherabbittibia(a),lengtheningwasper-
formed (b). The calcium sulfate pellet was made into the powder form (c).
ThemixedmaterialofcalciumsulfateandCMCwasinjectedintogroupI(d),
andonlytheCMCmediumwasinjectedintogroupII(e).Then,eachmaterial
was injected using a fluoroscopic guide (f).
Search WWH ::
Custom Search