Biomedical Engineering Reference
In-Depth Information
Chapter 43
EFFECT OF SCAFFOLDS WITH BONE
GROWTH FACTORS ON NEW BONE
FORMATION
Hae-Ryong Song,
a*
Swee-Hin Teoh,
b
Jun-Ho Wang,
e
Hak-Jun Kim,
a
Ji-Hoon Bae,
a
Sung Eun Kim,
a
Jerry Chan,
c
Zhi-Yong Zhang,
b
and Chang-Wug Oh
d
a
Rare Diseases Institute, Department of Orthopedic Surgery, College of Medicine,
Korea University, Seoul, Korea
b
Centre for Biomedical Materials and Applications (BIOMAT), Department of
Mechanical Engineering, National University of Singapore
c
Experimental Fetal Medicine Group, Department of Obstetrics and Gynaecology, KK
Women's and Children's Hospital and National University of Singapore, Singapore
d
Department of Orthopedic Surgery, Kyungpook National University Hospital,
Daegu, Korea
e
Department of Orthopedic Surgery, Samsung Medical Center, Seoul, Korea
*songhae@korea.ac.kr
Bone tissue engineering (BTE) using scaffolds with growth fac-
tors/stem cells has received some success in clinical trails.
Recently, osteogenic scaffolds using absorbable or nonabsorbable
biomaterials have being investigated to repair bone defects. Scaf-
folds can provide the osteoconduction effect as well as a media to
trap cells and allow them to proliferate and differentiate. Biore-
actors provide a means to uniformly coat the scaffolds with cells
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