Biomedical Engineering Reference
In-Depth Information
Chapter 42
REGENERATIVE MEDICINE
Dongwon Lee,
*
John M. Rhee, and Gilson Khang
Department of Polymer-Nano Science and Technology, Choubuk National University,
664-14, Dukjin, Jeonju, 561-756, Korea
*dlee@chonbuk.ac.kr
Hydrogen peroxide is a major reactive oxygen species (ROS) and
plays a fundamental role as a second messenger in normal cel-
lular signal transduction. The overexpression of hydrogen perox-
idehasbeenimplicatedininflammatoryresponsesandnumerous
life-threatening diseases. Therefore, hydrogen peroxide has great
potential as a diagnostic biomarker of inflammatory response.
Inflammation is considered one of the most important host reac-
tions to implanted biomaterials, and therefore how implanted
biomaterials influence inflammation is of central important in
determiningtheoutcomeofscaffold-basedregenerativemedicine.
Imaging of hydrogen peroxide in cells and tissues has been per-
formed by using optical probes that can react with hydrogen per-
oxide with high sensitivity and specificity and emit light. Optical
imaging allows us to watch the behavior of target biological mole-
cules in real time, providing temporal and spatial information on
biological molecules in cells and tissues. The development of opti-
cal probes for molecular imaging of hydrogen peroxide is now a
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