Biomedical Engineering Reference
In-Depth Information
Chapter 41
AN EFFICIENT
EX VIVO
EXPANSION OF
ADULT MESENCHYMAL STEM CELLS IN
SCAFFOLDS
EuiKyunPark,
a*
Hong-In Shin,
a
and Shin-Yoon Kim
b
a
Department of Oral Pathology and Regenerative Medicine, School of Dentistry,
b
Department of Orthopaedic Surgery, School of Medicine, Kyungook National
University 188-1 Samduk 2-ga, Jung-gu, Daegu, Korea
*epark@knu.ac.kr
Tissue engineering utilizing mesenchymal stem cells (MSCs) in
combination with scaffolds presents promising alternative ther-
apies for bone defects. Because of their low numbers in adult
tissues, most clinical applications of MSCs depend on isolation
followed by
ex vivo
expansion. The development of methods to
obtain su
cient quantities of MSCs, and to improve their safety
and functionality, could dramatically facilitate their use in clinical
applications in regenerative medicine. A number of papers have
demonstrated stimulatory effects of growth factors on prolifera-
tionanddifferentiationofMSCsinculture.Itisimportanttounder-
stand the biological effects of factors that regulate MSC activity.
This review will discuss the effects of growth factors on MSCs and
their mechanisms of action with respect to the e
cient
ex vivo
expansion of MSCsfor regeneration of hard tissue such asbone.
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