Biomedical Engineering Reference
In-Depth Information
Figure 40.5.
Macroscopic and histological evaluation of controls, PM,
and PM/dMSCs implantations at each time point.
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(A) Bone defects were
prepared with a trephine bar. Controls were defects only. (B, C) The defects
were filled by PM (B), PM/dMSCs (C). (D) At 8 weeks, bone regeneration
in the controls (defect only) was not complete. (E, F) After 8 weeks, new
bone regeneration was observed with PM (E) and PM/dMSCs (F). Sections
of representative implants are shown from each group. The sections were
stained with hematoxylin & eosin. Original magnification
×
100 (inner
×
square,
25) for all photographs. (G) 2 weeks control group, (H) 4 weeks
controlgroup,(I)8weekscontrolgroup,(J)2weeksPMgroup,(K)4weeks
PM group, (L) 8 weeks PM group, (M) 2 weeks PM/dMSCs group, (N) 4
weeks PM/dMSCs group, and (O) 8 weeks PM/dMSCs group. See also Color
Insert.
“injectable TEB,”
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-
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which had been established by the tissue
engineering concept.
5
PRP, one of scaffolds, which is a mixture of growth factors and
an autologous modification of the fibrin glue, is believed to result
in early consolidation and graft mineralization.
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The use of PRP is
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