Biomedical Engineering Reference
In-Depth Information
Figure 40.4.
Images of PM and PM/dog MSCs (dMSCs).
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(A) Molecular
model of the peptide RADA16-I included in PM. A; alanine. R; arginine. D;
asparticacid.-and
+
refertothenegativelyandpositivelychargedresidues.
(B,C)PhotographofPMhydrogelatnormaltemperature.(D,E)SEMimages
ofPM.ThePMsurfaceappearslikeasheet[D].dMSCsaresandwichedinPM
sheets at a higher magnification [E]. A scale bar on each image is included:
100 nm (D);10
μ
m (E). See also Color Insert.
aspartic acid and has greater than 99.5% water content (standard
amino acids content 1% w/v)
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and good fluid characteristics
(Fig. 40.4).
13
The peptides have regular repeating units of posi-
tively charged residues (arginine) and negatively charged residues
(aspartic acid) separated by hydrophobic residues (alanine) and
contain 50% charged residues and are characterized by their
periodic repeats of alternating ionic hydrophilic and uncharged
hydrophobic amino acids.
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The peptides interact individually
by self-complementary and amphiphilic properties and are self-
assembled. Thus, PM possesses good plasticity, absorption, and
biocompatiblepropertiesandisdevoidofanimal-derivedpathogens
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