Biomedical Engineering Reference
In-Depth Information
Figure 40.3.
TypicalhistologicalfindingofMSCsloadedin
β
-TCPscaffolds
and empty
β
-TCP at 1, 2, 4, and 8 weeks after implantation (bar
=
100
μ
m,hematoxylin&eosinstaining).
10
Empty
β
-TCP(A)1weekafterimplan-
tation, (C) 2 weeks after implantation, (E) 4 weeks after implantation, and
(G) 8 weeks after implantation. MSCs loaded in
-TCP scaffolds (B) 1 week
after implantation, (D) 2 weeks after implantation (V indicates vasculature,
and arrow indicates osteoblast lining), (F) 4 weeks after implantation, and
(H) 8 weeks after implantation.
β
and promotes and regulates cellular functions such as adhesion,
migration, proliferation, and differentiation and is consequently
involvedin three-dimensionalmorphogenesis.
11
PM is also a synthetic biological material formed through the
assembly of ionic self-complementary peptides consisting of a
16-amino acid sequence, Ac-RADARADARADARADA-CONH
2
,which
is called RADA16-I and is composed of alanine, arginine, and
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