Biomedical Engineering Reference
In-Depth Information
Chapter 40
REGENERATION
Yoichi Yamada
Center for Genetic and Regenerative Medicine, Nagoya University School of Medicine,
Nagoya, Japan
yyamada@med.nagoya-u.ac.jp
Bone defects often occur due to various diseases, and the golden
standard approach to the treatment is autogenous bone grafting.
However,thebonecollectinginvolvednotonlysevereinvasiveness
with attendant donor site morbidity and complications but also
the limited supply of autogenous material. For overcoming this
problem, various artificial materials containing ceramic material,
syntheticbiologicalmaterial(nanomaterial),andbiomaterialhave
beendeveloped.Thischapterhasfocusedontheuseofbiodegrad-
able scaffolds, especially biodegradable ceramic composites
(
β
-tricalcium phosphate [
β
-TCP]), nanofibers hydrogel peptide
(PM), and injectable biomaterial—tissue-engineered bone (TEB).
TEB consists of platelet-rich plasma (PRP) as the scaffold and
signal molecules and mesenchymal stem cells (MSCs) as the
isolated cells for effective bone regeneration applied by tissue
engineering and the regenerative medicine concept. According to
the animal study and clinical applications, these materials would
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