APPLICATION OF SCAFFOLDS FOR ARTIFICIAL SKIN IN REGENERATIVE MEDICINE - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 810

Table 39.1. ( Continued )

Main component & Description Characterization

commercial product
name (Manufacturer)
Dermagraft R Cryopreserved,

allogeneic
fibroblast-derived
dermalmatrix

Neonatal fibroblast rapidly and
easily proliferated to produce
some growth factorsto aid in
woundhealing. Tends to have
been usedas a biological
dressing with multiple
applications, even if it does not
clearlydemonstrate rejection,
and is veryresistant totearing.

(Advanced
Biohealing, Inc.)

(Johnson &
Johnson)

Integra R Synthetic polysilox-

ane polymer;
bovinetypeIcollagen
and GAGs

Encouragesingrowth of
fibroblasts and epithelial cells.
Epidermalequivalentreplaced
after 14-21 dwith an autograft.
Bovine collagen presents and
antigenicity and disease risk.

Transcyte R Thin silicone layer

over collagen-coated
nylonmesh seeded
with neonatal
allogeneic fibroblasts

It'snot marketedcurrently,but
successfullyused to treat second-
and third-degree burns. Dermal
fibroblasts secrete collagen;
GAGsand growth factorsto aid
woundhealing. Problems are
nylonmesh (not biodegradable),
rejection, and disease risk from
fibroblasts.

(Advanced
Biohealing, Inc)

(Brennen Medical,
LLC)

EZ-Derm R Porcine-derived

xenograft in which
thecollagen hasbeen
chemically
cross-linked with an
aldehyde

Temporary, protectivebarrier
thatallows thenaturalhealing
process to continue undisturbed,
keepsbody fluids in and bacteria
out; aldehydecross-linking adds
strength and durability for
extended wound coverage.

Repliform R Acellularhuman

dermalallograft

Application for urological plastic
surgery.Repeated application
needed.

(LifeCell
Corporation)

(Organogenesis
Inc.)

FortaFlex R Acellularporcine

small intestine
submucosa

Application to treat full- and
partial-thickness burns, venous
anddiabetic ulcers. Rejection and
disease risk. Repeated
application needed.

( Contd. )