Biomedical Engineering Reference
In-Depth Information
graft materials, further
in vivo
performance and clinical studies are
neededtoconfirmtheirpromiseaseffectivegraftmaterialsforbone
regeneration.
In our recent research, the nano-HA/collagen/PLA composites
have been used to repair a 20 mm segmental defect in the radius
of the beagle dog. The X-ray and histological observations demon-
strated that the 20 mm segmental defect was completely healed
within 24 weeks after surgery, as shown (Fig. 37.5). The results of
theanimalstudiesconfirmtheexcellentbiocompatibility,osteocom-
patibility, and bioactivity of the composites with surrounding tis-
sues, and the implants were observed to stimulate the formation of
new bone.
(a)
(b)
(c)
(d)
Figure 37.5.
TheX-ray(a,b,andc)andhistological(d)observationsofthe
nano-HA/collagen/PLAcompositestorepaira20mmsegmentaldefectina
dog. (a) After surgery; (b) implant at 12 weeks; new bone and callus grew
up, and cortical bones were connected completely; (c) implant at 24 weeks;
bonecallusdecreasedwiththecompleterepairbynewbone;(d)implantat
24 weeks; histology H&E staining; bone marrow appeared in the new bone
tissue.
Abbreviation
: H&E, hematoxylin and eosin.
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