Biomedical Engineering Reference
In-Depth Information
Figure 37.1.
Thesevenhierarchicallevelsoforganizationofthezebrafish
skeleton bone.
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Level 1: HA crystals and part of a collagen fibril with the
triplehelixstructure.Level2:Mineralizedcollagenfibrils.Level3:Thearray
ofmineralizedcollagenfibrils.Level4:Twofibrilarraypatternsoforganiza-
tionasfoundinthezebrafishskeletonbone.Level5:Thelamellarstructure
in one vertebra. Level 6: A vertebra. Level 7: Skeleton bone.
materials, such as tissue engineering scaffold materials and bio-
mimetic engineering materials. The key steps in the composite syn-
thesis of mineralized collagen are control of nucleation and growth
of calcium phosphate minerals by collagen matrix and assembly of
the nanofibrilofmineralized collagen in aqueous media.
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37.3.1
Mineralization Mechanism of Hydroxyapatite
Crystals on Collagen Fibers
The study of biomineralization is not only important to gain an
understanding of how mineral-rich tissues are created
in vivo
but
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