Biomedical Engineering Reference
In-Depth Information
Chapter 37
TISSUE REGENERATION
Fu-Zhai Cui,
*
Zong-Gang Chen, and Xue Xia
Department of Materials Science and Engineering, Tsinghua University,
100084, Beijng, P.R. China
*cuifz@mail.tsinghua.edu.cn
This paper presents a review of collagen-based scaffolds for bone
tissue regeneration by self-assembling. On the basis of discussing
the component and hierarchical structure in natural bone tissue,
the biomemitic fabrication of collagen-based bone tissue engi-
neering scaffolds using self-assembled collagen mineralization
and their current applications and development in bone tissue
regeneration are described. Some basic questions of biomemitic
fabrication concerning the composition, microstructure, crystal-
lography, and organic-inorganic phase relationships have been
reviewed. This kind of bone graft composite has already shown
greatpromiseandsuccessinclinicalapplications,onaccountofits
compositional and structural similarity to natural bone. It is sug-
gestedthatfutureworkinthisshouldfocusonbothbasictheoret-
ical aspects, as well as the development of applications.
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