Biomedical Engineering Reference
In-Depth Information
experimental and positive control groups in electroconductivity, the
velocity,ortheamplitudeofactionpotentials.Histologyalsodemon-
strated that the level of axon regeneration in the tissue-engineered
nerve was comparable to that of the positive control group
(Fig. 34.21).
8
34.8 Conclusion
This chapter reviewed the recent accomplishments in tissue recon-
struction in our center. The results showed that it is possible to
generate different types of soft tissues, such as tendon, cartilage,
skin, cornea, vessel, and peripheral nerve, either
in vitro
or
in vivo
by using PGA fibers as the main scaffold, indicating PGA fibers
remain one of the excellent candidates of scaffold materials for
soft-tissue engineering, although they are considered conventional
materials and have been used since the early stage of tissue engi-
neering research. Future efforts to modify PGA fiber characters for
reduced acidity of its degradation product, better regulation of its
degradability, and enhanced mechanical property will be the future
direction to better use PGA fibers as the scaffold for soft-tissue
engineering.
Acknowledgments
These studies were supported by the National “973” and “863”
Tissue Engineering Project Foundation, the Shanghai Science and
Technology Development Foundation, the Key Laboratory Founda-
tion of Shanghai Education Committee, and the National Natural
Science Foundation. The authors would like to thank Drs. Yong-
tao Liu, Bin Chen, Dejun Cao, Feng Xu, Dan Deng, Bin Wang, Yan-
jie Zhang, and Hong Li for the contribution in tendon engineer-
ing; Drs. Guangdong Zhou, Yanchung Liu, Fuguo Chen, Yimin Cui,
Tianyi Liu, and Kai Liu for the contribution in cartilage engineer-
ing; Drs. Guanghui Yang, Xie Cai, Jun Yang, and Chengliang Deng
for the contribution in skin engineering; Drs. Zhicheng Xu and Yang
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