Biomedical Engineering Reference
In-Depth Information
Figure 34.2.
Repair of tendon defects by gross view of a fibroblast engi-
neered tendon (a and d, between arrows), a tenocyte-engineered tendon
(b and e, between arrows), and a formed tissue in control group 2 (c and
f, between arrows) at 26 weeks. Note that both engineered tendons have a
relatively smooth surface, whereas the control tissue has a rough surface.
(a-c) Before harvesting; (d-f) after harvesting. (Reprinted by permission
from Ref.12).
dermal fibroblasts and tenocytes that were seeded onto the scaf-
fold, indicating good cell compatibility between the cells and
the scaffold. The prefabricated cell-scaffold construct was trans-
planted
in vivo
to repair a 3 cm long defect created on the
flexor digitorum superficialis tendon. When examined at 26 weeks'
postrepair, mature tendon tissue was formed, which was simi-
lar to the tendon tissue engineered by autologous tenocytes in
a gross view (Fig. 34.2). Histologically, a similar tissue structure
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