Biomedical Engineering Reference
In-Depth Information
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Figure 1.8.
An SPCL scaffold with different geometry fabricated by the
rapidprototypemethodfortheapplicationoftheregenerationofthespinal
cord.
better cell migration and nutrient perfusion. Figure 1.8 shows a
starch-polycaprolactone (SPCL) scaffold with different geometry
fabricated by the rapid prototype method for the application of the
regenerationofthespinalcord.Afterseedingtheolfactoryensheath-
ingcells,cellsinSPCLscaffoldsproliferatedcontinuouslyfor28days
andnoadverseeffectsofSPCLwereobserved.ItseemsthattheSPCL
scaffolds with a highly porous microstructure favor nutrient supply,
waste removal, and cell migration, facilitating cell proliferation.
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One of the first rapid prototyping devices to be developed for
the tissue engineering application was 3DP. Briefly, the desired fea-
ture of a diseased organ form can be fabricated by depositing by a
CAD/CAM-controlled manner a jet of solvent on top of a polymer
powder bed. The solvent binds the powder, resulting in the forma-
tion of a pattern of fibers, built layer by layer. Similary, SLS consists
of projecting a laser beam that can sinter the powder by local high
temperature on a polymeric powder bed. Laser ablation is carried
out to ablate the scaffold materials in a specific form using a laser
beam.
These techniques are able to fabricate the periodic struc-
tures with well-defined, controlled, and completely interconnected
porosity.
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