Biomedical Engineering Reference
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Figure 30.12.
HistologicalsectionsofPCLscaffoldsectionswithdifferent
pore sizes (
×
100;
∗
, host bone; arrow, new bone) (Ref.28).
∼
μ
into the center of the scaffold. The scaffold section having
m
poresizealsoshowednewboneformation(butlessthanthescaffold
section with
∼
310
μ
m pore size); however, in the other group sec-
tionshavinglessthan
∼
310
μ
mporesize,verylimitedbonegrowth
behavior was observed. It seems that the pore size of about 310
μ
m
issu
cientforbonetissueingrowthinourexperimentsystem,even
though the result of this preliminary animal study was a little dif-
ferent from the
in vitro
osteoblast growth behavior: the osteoblasts
showed better cell growth in the scaffold section having
∼
405
μ
m
pore size than the scaffold section with
∼
310
μ
m pore size (see Fig.
30.11b).Actually,withrespecttoboneregeneration, therearesome
inconsensus regarding the optimal scaffold pore sizes. Hulbert
et
al
.
21
reported that the scaffolds with pore sizes larger than 150
μ
m
weresuitableforbonereorganizationandingrowth,whileRobinson
et al
.
18
reported that the bone formation and ingrowth occurred in
scaffolds within a 350
μ
m pore size, but the scaffolds with a pore
sizeless than 200
μ
m had noboneingrowth.
It was also reported that excellent bone ingrowth occurred in
scaffolds with pore sizes larger than 400
405
m.
19
,
20
It seems that the
μ
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