Biomedical Engineering Reference
In-Depth Information
Chapter 30
NOVEL FABRICATION AND
CHARACTERIZATION OF
PORE-SIZE-GRADIENT SCAFFOLDS
BY A CENTRIFUGATION TECHNIQUE
Se Heang Oh and Jin Ho Lee
*
Department of Advanced Materials, Hannam University
461-6 Jeonmin Dong, Yuseong Gu, Daejeon, Korea
*jhlee@hnu.kr
It is well recognized that the pore size of polymer scaffolds plays
an important role for cell growth and tissue regeneration: dif-
ferent kinds of cells were shown to have different optimal pore
size ranges in the scaffolds for effective cell growth. So, if the
tissue scaffold with a pore size gradient (i.e., the scaffold with
gradually increasing pore size along one direction) can be pre-
pared, it will become a powerful tool for basic studies of the
interactions between cells or tissue and scaffolds with different
pore sizes since the effect of pore size can be effectively exam-
ined using one scaffold. In recent years, several techniques have
been used to fabricate porous polymer scaffolds having a three-
dimensional (3D) pore structure. However, it is not possible from
those techniques to fabricate scaffolds with a pore size gradient.
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