Biomedical Engineering Reference
In-Depth Information
Chapter 28
ENGINEERING
Young-KwonSeo
a
andJung-Keug Park
a,b*
a
Dongguk University Research Institute of Biotechnology, Dongguk
University, Seoul, 100-715, Korea
b
Department of Medical Biotechnology, Dongguk
University, Seoul, 100-715, Korea
*jkpark@dongguk.edu
Woundhealingisachievedviathesynergisticeffectofcells,growth
factors, and scaffolds, all of which play important roles. Tissue
engineering provides a promising solution for the repair of tis-
sue defects. Scaffolds provide substrates to which cells can attach
during the initial phase of repair that degrade after the comple-
tion of wound healing. Various natural materials, including col-
lagen, hyaluronan, silk, and synthetic degradable polymers such
as polyglycolic acid (PGA), polylactic acid (PLA), and polycapro-
lactone (PCL), have been investigated extensively for their abil-
ity to support the growth of cells. However, scaffolds constructed
from these compounds have various problems associated with
their mechanical properties and biocompatibility. To obtain good
repair, scaffolds should not only possess properties that support
cell adhesion, growth, and differentiated function, but must also
create a stable, three-dimensional structure with su
cient poros-
ity and mechanical properties to facilitate repair. Specifically, a
Search WWH ::
Custom Search