CONSIDERATIONS ON THE STRUCTURE OF BIOMATERIALS FOR SOFT- AND HARD-TISSUE ENGINEERING - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 519

Figure 26.6. Maximum tensile strength of electrospun scaffolds and
nativetissues.PCLscaffoldswere3timesstrongerthantheaortaandPTFE.
Abbreviations : CA, carotid artery; JV, jugular vein; AO, aorta; IVC, inferior
vena cava; PTFE, polytetrafluoroethylene graft.
slight changes in materials could significantly affect nanoscaled
structures. Since adhesion and infiltration of the cells depends on
the structure of the scaffold, the difference in material constituents
could affect biocompatibilityofthe electrospun nanofiberscaffold.
The tensile strength of the scaffold was measured, and the break
points(maximumtensilestrength)ofthePLA,PLAwithelastin,and
PCL were compared with canine carotid artery, jugular vein, infe-
riorvenacava,aorta,andpolytetrafluoroethylene(PTFE)tubes.The
tensile strength of PCL was three times that of the aorta and PTFE.
However, the tensile strength of PLA and PLA with elastin was more
fragile than that of the vein (Fig. 26.6).
Compliance tests were performed by our original compliance
measurement system (Fig. 26.1). This system is able to observe
pressure and cross-sectional diameter or area relationship of the
prostheses. 2 The cross-sectional area of PLA with elastin increased
in response to high-pressure load, but the response was different
thanthenativeartery.Infact,thepressure-arearelationcurveofPLA
with elastin was approximately linear. On the other hand, PCL and
PLAshowedanoncompliantresponseandalmostnocross-sectional
area change, which was similar to the PTFE tube. It is important
to emphasize the fact that compliance tests by our original system
can measure the compliance of material in conditions similar to