Biomedical Engineering Reference
In-Depth Information
microarchitecture within 3DP scaffolds, which may influence cell
behavior and degradation of the scaffold, but this microarchitecture
is uncontrolled.
15
,
56
The material choice for 3DP is limited as most
biomaterials for tissue engineering purposes are not available in
powder.Despitethisstudieshavesuccessfullydemonstrated3DPas
a viable method to create a scaffold that supports new bone forma-
tion in a critical-sized defect. Even with these valuable studies, only
alimitedamountofresearchhasbeendonetoassessthe
in vitro
and
in vivo
osteoinduction and osteoconduction of 3DP-fabricated scaf-
folds,andconsiderablymoreworkneedstobedonetodemonstrate
theutilityof3DPforcell-basedbonetissueengineeringapplications.
25.4 Selective Laser Sintering
25.4.1
Scaffold-Manufacturing Process
Like 3DP, scaffolds designed via SLS begin with a powder mate-
rial (Fig. 25.3). The powder material is placed on a flat bed and
Figure 25.3.
A schematic of the SLS process.
1
,
20
The polymer in the pow-
der bed is sintered by the laser, which can be moved in the x-y direction.
Thebuildingplatformisloweredbyalayerthickness,andthepowderroller
adds additional powder to achieve three dimensionality.
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