Biomedical Engineering Reference
In-Depth Information
Chapter 25
BIOLOGICAL IMPLICATIONS OF
POLYMERIC SCAFFOLDS FOR BONE
TISSUE ENGINEERING DEVELOPED VIA
SOLID FREEFORM FABRICATION
Andrew B. Yeatts and John P. Fisher
*
Fischell Department of Bioengineering, University of Maryland,
College Park, MD 20742, USA
*jpfisher@umd.edu
Clinically viable cell-based bone tissue engineering strategies
require the development of advanced scaffold-manufacturing
techniques. Stereolithography (SLA), three-dimensional printing
(3DP), selective laser sintering (SLS), and fused deposition mod-
eling(FDM)allareadvancedsolidfreeformfabrication(SFF)tech-
niques with bone tissue engineering applications; however, each
presents a unique set of benefits and drawbacks. These bene-
fits and drawbacks relate to the ability of the scaffolds to sup-
portcellproliferation,migration,anddifferentiation.SFFscaffolds
are manufactured with a controlled architecture, but all methods
reviewed have significant limitations with regard to the type of
polymer used and resolution that can be obtained, both of which
have great biological implications on cell and tissue interaction
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