Biomedical Engineering Reference
In-Depth Information
21.6 Summary
In this chapter, we have presented a summary of the published
worksonthedesignofbiomimeticscaffoldsforlivertissueengineer-
ing. The galactose-carrying synthetic and natural polymers among
the artificial ECMs through bulk or surface modification of bioma-
terials can guide hepatocyte behaviors such as adhesion, morphol-
ogy, proliferation, migration, differentiation, and survival through
receptor-mediated interaction between ASGPR on hepatocytes and
galactose moieties in the biomimetic scaffolds. Also, the topology of
the ECM, coculture, and the cell source affected hepatocyte behav-
iors. The precise design of galactose-carrying biomimetic scaffolds
asartificialECMswillcontributetolivertissueengineeringasanew
system of bioartificial liver-assist devices or regeneration of liver
tissue substitutes, although the hepatocellular-signaling pathway in
the biomimeticscaffoldsshould beperformed in the future.
Acknowledgments
We would like to acknowledge Miss Ji-Hye Seo for typewriting this
chapter.
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