Biomedical Engineering Reference
In-Depth Information
Figure 1.3.
Photomicrographs of H&E stain sections of the directly bor-
dering tissue after PLGA, hybrid PLGA/DBP films, and DBP. (A) The tis-
sue implanted with PLGA, bar length = 100
μ
m (x100), (B-F) The tissue
implanted with 10% DBP/PLGA, 20% DBP/PLGA, 40% DBP/PLGA, 80%
DBP/PLGA, and DBP, respectively, bar length = 50
m (x400). Note that
the number of inflammatory cell and fibrous band thickness in vicinity to
tissue-implanted samples was decreased as DBP content in PLGA film was
increased.Polymer-tissueinterfacesurfacesareindicatedbyawhitearrow.
The fibrous wall thickness was represented by black and white arrows.
Abbreviations
: H&E, hematoxylin and eosin.
μ
Figure1.3showstheeffectofDBPonthereductionofinflammatory
reaction from the host tissue for a DBP/poly(lactide-
co
-glycolide)
(PLGA)hybridscaffold.AfterthehybridizationofDBPintoPLGA,the
numberofmononuclearphagocytecellsandthethicknessoffibrotic
wall thickness were dramatically decreased. It offers good informa-
tion to design a natural scaffold(explained in chapter 16).
13
The porosity, such as the size of the mean diameter and the
surfacearea,isacriticalfactorforthegrowthandmigrationofatis-
sueintothebioceramicscaffolds.
9
Severalmethodswereintroduced
to optimize the fabrication porous ceramics, such as dip casting,
starch consolidation, polymeric sponge method, foaming method,
organic additives, gel casting, slip casting, direct coagulation
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