EXTRACELLULAR MATRIX–BASED SCAFFOLDS FROM SCRATCH - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 385

Chapter 20

EXTRACELLULAR MATRIX-BASED
SCAFFOLDS FROM SCRATCH

Willeke F. Daamen, a* Kaeuis A. Faraj, a,c Martin J. W. Koens, a
Gerwen Lammers, a Katrien M. Brouwer, a
Peter J. E. Uijtdewilligen, a Suzan T. M. Nillesen, a Luc A. Roelofs, b
Jody E. Nuininga, b Paul J. Geutjes, b Wouter F. J. Feitz, b
and Toin H. van Kuppevelt a
a Radboud University Nijmegen Medical Centre, Department of Biochemistry (280),
P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
b Radboud University Nijmegen Medical Centre, Department of Urology (659),
P.O. Box 9101, 6500 HB Nijmegen, The Netherlands
c aaP Bioimplant - EMCM BV, Middenkampweg 17, 6545 CH Nijmegen, The Netherlands
*[e-mail]

In this chapter, the preparation of extracellular matrix (ECM)-
based scaffolds from scratch is described. For applications in soft
tissue engineering and regenerative medicine, scaffolds based on
ECM proteins like collagen and elastin can be prepared with both
a known architecture and a defined composition. In combina-
tion with appropriate modulating molecules, like growth factors,
this may yield scaffolds containing the correct cues and signals
to trigger regeneration of specific tissues in vivo . The construc-
tion of innovative scaffolds with a defined molecular composi-
tion, morphology and shape will be described in this chapter. The