SUPPRESSION OF INFLAMMATORY REACTIONS ON MPC POLYMER SURFACES - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 375

Table 19.1. Characterization of polyphosphate hydrogels.

MPC/OPEMAunit in PIOP a (mol%) Heq b (wt%) Abbreviation

PCPG 1.0 99.0/1.0 90.2

PEPG 1.0 99.0/1.0 83.3

a [Monomer] = 1.0 mol/L, [AIBN] = 5 mmol/L.
b Hydration degree (Heq) = (weight of water in polymer membrane/weight of
polymer membranesaturatedwith water) × 100.

the PCPG. Mikos et al. reported that implantation of a biomaterial
initiatesasequenceofeventssimilartoaforeignbodyreactionstart-
ingwithanacuteinflammatoryresponseand,insomecases,leading
to a chronic inflammatory response and/or development of granu-
lation tissue, development of a foreign body reaction, and develop-
ment of a fibrous capsule. 44 During the early stages, inflammatory
cells such as neutrophils and monocytes accumulate on biomate-
rials implanted in soft tissue. On the PEPG, an acute inflammatory
response occurred.
Figure19.9bshowsopticalmicrographsofthesubcutaneoustis-
sueincontactwiththehydrogelsfor28days.Alayeroffibrouscells

(a)

PCPG1.0 PEPG1.0

(b)

PCPG1.0 PEPG1.0

Figure 19.9. Histological micrographs of subcutaneous tissue in contact
with hydrogel for (a) 7 days and (b) 28 days. The smashed gels are artifacts
from histological preparations. Abbreviations : IC, inflammatory cell; L, lipid
tissue; V, blood vessel; FC, fibrous capsule.