Biomedical Engineering Reference
In-Depth Information
such as coagulation factors, lysosomal enzymes, cytokines, and
growth factors. The proinflammatory cytokines, interleukin-1
β
(IL-
1
β
), IL-6, and tumor necrosis factor-alpha (TNF-
α
) are multifunc-
tional soluble mediators that affect various types of cells. The
secretion level of these proinflammatory cytokines is different with
the activation state.
19
IL-1
mediates the activation and prolifera-
tion of lymphocytes, fibroblasts, and endothelial cells.
20
Recently,
numerous studies of the interaction between macrophages and
materials have been conducted to understand the biocompatibil-
ity of materials.
21
-
27
In these reports, cytokine production from
macrophages was evaluated using the enzyme-linked immunosor-
bentassay (ELISA).
22
-
24
We have hypothesized that the MPC polymers reduce not only
protein/material interactions but also cell/material interactions,
including the inflammatory response of cells.
As shown in Fig. 19.4, the amount of proteins adsorbed on PMB
from a cell culture medium containing fetal plasma was lower than
β
Figure 19.4.
Amount of proteins adsorbed on polymer surfaces from cell
culturemedium.Meanvaluesofsixmeasurementsandstandarddeviations
are indicated.
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