Biomedical Engineering Reference
In-Depth Information
Figure 19.2. Chemical structure of MPC.
compoundsbyconventionalradicalpolymerization.Thismeansitis
very easy to design MPC polymer structures to adapt to substrates
that are modified with the MPC polymer. Controlling the monomer
ratio determines the MPC unit composition in the polymer. MPC
polymerswerealsopreparedwithotherpolymerarchitecturessuch
as block-type copolymers and graft-type copolymers by a conven-
tionalradicalpolymerizationtechnique. 7 - 8 Recentadvancementsin
radical polymerization have provided well-defined polymers. That
is,livingradicalpolymerizationofMPCcouldbereported,andsmall-
molecular-weight-dispersion polymers were obtained. 9 - 10 In addi-
tion, living polymerization could facilitate the making of block-type
polymers. Surface-initiated living radical polymerization has been
proposed to prepare a brush-type polymer graft layer. These func-
tionalMPC polymers are useful forsurface modification.
One of the MPC polymers used in implantable medical devices
is poly(MPC-co-n-butyl methacrylate [BMA]) (PMB). We have inves-
tigated the blood compatibility of PMB, with special focus given to
each blood component, for example, cells, plasma protein, phospho-
lipids, and water. 11 - 18
Figure 19.3 shows experimental columns containing polymer-
coated poly(methyl methacrylate) beads and micrographs of the
beadsurfaceaftercontactwithhumanbloodwithoutanyanticoagu-
lant. On the poly(BMA), which did not have MPC units, many adher-
ent bloodcellswere observed and clotswere formed.
 
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