SYNTHETIC/NATURAL HYBRID SCAFFOLD FOR TISSUE REGENERATION - Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine - page 332

1.2

1.0

0.8

0.6
0.4

0.2

0.0

PLGA S10 S20 S40 S80
SIS content (%)
(A)

1.2

1.0

0.8

0.6

0.4

0.2

0.0

PLGA S10 S20 S40 S80
SIS content (%)
(B)

1.2

1.0

0.8

0.6

0.4

0.2

0.0

PLGA S10 S20 S40 S80
SIS content (%)
(C)

Figure 16.16. The expression of TNF- α IL-1 β and IL-6 mRNA in vivo fell
continuously with an increase in the content of SIS in PLGA. (a) TNF- α
expression significantly decreased in each scaffold as SIS content increased
from 0% to 80%; (b) IL-1 β mRNA expression decreased markedly on 40%
and80%SIS/PLGAfilms;(c)IL-6mRNAexpressiondecreasedmarkedlyon
40%and80%SIS/PLGAfilms.*correspondsto p < 0.05incomparisonwith
PLGA films.