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Figure 16.11.
The expression of IL-1
β
mRNA on HL-60 cells fell continu-
ously with an increase in the content of DBPs in PLGA. IL-1
β
mRNA expres-
sion decreased markedly on 40% and 80% DBP/PLGA films. * corresponds
to
p
<
0.05 in comparison with PLGA films.
the tissue surrounding the PLGA films; however, this inflammatory
reaction was progressively diminished with an increase in the con-
tent of DBPs in PLGA films. We observed numerous recruited neu-
trophils infiltrates with a large number of multinucleated giant
cells (MNGCs) in adjacent tissue after PLGA film implantation.
However, this inflammatory cellular response decreased as the
Figure 16.12.
The inflammatory response to PLGA films, DBP hybrid
PLGAfilms,andDBP.Thedensityofinflammatorycells.*correspondsto
p
<
0.05 in comparison with PLGAfilms.
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