Biomedical Engineering Reference
In-Depth Information
Chapter 16
FOR TISSUE REGENERATION
Gilson Khang,
a*
Soon Hee Kim,
a
Su Hyun Jung,
a
and Yun Sun Yang
b
a
Deptof BIN Fusion Tech. andDept ofPolymerNano Sci. &Tech.,
Chonbuk Nat'lUniv., 664-14Dukjin,Jeonju,561-756Korea
b
MedipostBiomedical Research Institute,MedipostCo., Ltd., 1571-17,
Seocho3-dong, Seocho-Gu, Seoul, 137-874Korea
*gskhang@chonbuk.ac.kr
α
For the scaffold materials, the family of poly(
-hydroxy acid)s,
such as polyglycolide (PGA) and polylactide (PLA) and its copoly-
mers like poly(lactide-
co
-glycolide) (PLGA), is extensively used or
tested in the area of tissue-engineered organs as a bioerodible
materialduetogoodbiocompatibility,controllablebiodegradabili-
tiy,andrelativelygoodprocessability.However,itismoredesirable
to endow the PLA, PGA, and PLGA scaffold with new functionality
fortissue-engineeredbioorgans.Thischapterintroducesthefocus
of synthetic/natural hybrid biomaterials as PLGA/fibrin in order
to approach to a more natural three-dimensional (3D) environ-
ment and support biological signals for tissue growth and reorga-
nizationofchondrocyteandintervertebraldisc
invitro
and
invivo
.
Also, the reduction of inflammatory reaction of PLGA through the
hybridization of demineralized bone particles (DBPs) and small
intestine submucosa (SIS) has been reviewed for the supporting
of the information of the design of tissue-engineered scaffolds.
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