Biomedical Engineering Reference
In-Depth Information
containingornotcontainingbiomolecules(Fig.14.6). 50 , 51 Whilethe
core solution secures drug-loading e ciency and stability, the shell
polymer layer controls the release profile of the biomolecules. To
gain optimal delivery potential, the selection of materials and solu-
tionsfor the core and shellparts should beconsidered.
14.5 Concluding Remarks
Nanofibrous-structuredmaterialsholdgreatpotentialfortheregen-
eration of tissues, including bone. Electrospinning has become a
facile tool for creating nanofibers from a variety of compositions,
such as degradable polymers and bioactive inorganics. In terms of
mechanical and biological aspects, the composite approach is con-
sidered an appropriate way of producing a matrix that mimics the
native bone ECM. Moreover, surface functionalization with bone
mineral or bioactive molecules improves biological reactions at the
interface, stimulating cell adhesion, growth, and matrix formation.
Bone-targeting proteins and genes are currently introduced within
the nanofiber matrix to elicit therapeutic effects that ultimately
control cellular events and bone formation. With new ideas on elec-
trospinning and the development of compositions qualified for an
artificialboneECM,bonetissueengineeringusingnanofibrousscaf-
folds may be realized in the near future.
Acknowledgments
This work was supported by the Priority Research Centers Pro-
gram (grant#: 2009-0093829) and WCU (World Class University)
program (grant#: R31-10069) through the National Research Foun-
dation (NRF) funded by the Ministry of Education, Science and
Technology.
References
1. M. M. Stevens, Materials Today , 11 ,18 (2008).
2. D. W. Hutmacher, Biomaterials , 21 ,2529 (2000).
 
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