Biomedical Engineering Reference
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to hundreds of nanometers as the sol concentration was varied
(Fig. 14.2). When rBMSCs were cultured on the bioactive glass
nanofiber, they favorably migrated over and secreted an osteoblas-
tic differentiation phenotype. The differentiation level was signifi-
cantlyhigheronthenanofiberformofbioactiveglassthaneitheron
the dense sintered bioactive glass or on the nanofiber form of the
Figure 14.2.
Bioactive inorganic nanofibers obtained by electrospinning:
(a) SEM image of bioactive glass nanofibers produced by electrospin-
ning and heat treatment; (b) TEM image of acellular bone bioactivity of
nanofibers, showing the formation of bone mineral-like apatite on the
surface after soaking in SBF for 3 days (adapted with permission from
Ref. 25; copyright 2006 Wiley-VCH Verlag GmbH & Co.); (c) Rat BMSCs
grown on bioactive glass nanofibers for 7 days showing cells were viable
with active cytoplasmic extensions in contact with the underlying nanofi-
brous substrate.
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